Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine – PMC

2) has two ionizable hydroxyl groupsnHighlight:At a physiological pH, vitamin C exists predominantly as a monoanion, i.e., ascorbate monoanionnHighlight:DHA is commonly known as the oxidized form of vitamin C. Likewise, ascorbic acid (AscH2 or AscH)nHighlight:vitamin C can be considered as a generic name referring to both ascorbic acid and DHAnHighlight:highest tissue concentrations of vitamin C are found in the brain and in neuroendocrine tissues, especially adrenal glands, which may range from 1 to 3 mMnHighlight:sodium-dependent vitamin C transporters and (ii) glucose transportersnHighlight:reduced form of vitamin C is transported into cells via sodium-dependent vitamin C transporters (SVCT1 and SVCT2)nHighlight:Fourteen glucose transporters (GLUTs) are expressed in the human,nHighlight:GLUTs 1, 3, and 4, have been shown to also transport the oxidized form of vitamin C (i.e., DHA) from extracellular milieu into cellsnHighlight:treatment with parenteral vitamin C (given either intravenously or intraperitoneally) results in: (i) suppression of oxidative stress and NF-κB-driven pro-inflammatory responses; (ii) amelioration of microcirculation abnormalities and multiorgan dysfunction, and (iii) improvement of survivalnHighlight:combination of vitamin C with glucocorticoid drugs shows synergistic effects in treating experimentalnHighlight:prooxidative potential of mega-dose vitamin C has been harnessed to treat various types of cancern]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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