The Targeting of Phosphoinositide-3 Kinase Attenuates Pulmonary Metastatic Tumor Growth Following Laparotomy

P < 0.001), and enhanced postoperative survivalnHighlight:tumor removal is associated with an acceleration in both local and systemic tumor growthnHighlight:the surgical process itself creates a permissive environment in which the growth of residual neoplastic disease may be potentiatednHighlight:postoperative phenomenon is associated with reduced apoptosisnHighlight:accelerated local tumor recurrence is also associated with reduced apoptosisnHighlight:accelerated tumor recurrence (at the local level) is associated with increased phosphoinositide-3 kinase (PI3k) activitynHighlight:PI3k is associated with enhanced chemoresistance, particularly to potent chemotherapeutic agentsnHighlight:accelerated local recurrence following tumor cytoreductionnHighlight:Pidgeon et al have demonstrated an acceleration in metastatic tumor growth following laparotomynHighlight:several studies indicate that the process of tumor removal (ie, the surgical process) may potentiate the growth of residual neoplastic diseasenHighlight:outcome for patients who underwent tumor removal is not always as good as outcome in patients managed expectantlynHighlight:neoplastic cells exhibit a predilection for sites of tissue traumanHighlight:temporal advancement in the death specific hazard ratio for women who undergo mastectomy versus those managed expectantlynHighlight:PI3k is strongly implicated in neoplasianHighlight:following laparotomy, pulmonary metastatic tumor growth is increasednHighlight:strongly associated with reduced levels of apoptosisnHighlight:it is systemic disease that is the principal cause of mortality associated with solid tumorsnHighlight:surgical process, as described above, can potentiate metastatic tumor growtnHighlight:the targeting of PI3k completely protected against the potentiating effects of laparotomy and also appeared to reduce spontaneous metastatic tumor growthnHighlight:PI3k/Akt pathway in both spontaneous metastasis formation and, also, in accelerated metastatic growth following laparotomy.nHighlight:

PI3k/Akt plays a major role in regulating tumor recurrence at the systemic level.

nHighlight:The activation of PI3k in turn leads to increased Akt phosphorylation. The result of the latter is to reduce overall levels of apoptosisn]]>

Picture of About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.

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