Pharmacokinetics of cannabidiol in a randomized crossover trial in senior horses in: American Journal of Veterinary Research Volume 83 Issue 9 (2022)

1/2λ) CBD was 7.22 ± 2.86 hours for oral administration (2 mg/kg) or 3.15 ± 2.19 hours for IV administration (0.1 mg/kg),nHighlight:mean time to reach maximum concentration (Tmax) was 2.46 ± 1.62 hours after oral administrationnHighlight:Mean ± SD oral bioavailability (F) for CBD administration in senior horses was 7.92% ± 2.85%.nHighlight:There were no meaningful differences in results of any of the CBC or serum biochemical analyses measures prior to or 24 hours after oral or IV administration of CBDnHighlight:There were no meaningful effects of CBD dosing on any of the vital signs measured (rectal temperature, pulse, and respiratory rate) at 30 minutes and 1 hour after administrationnHighlight:After oral or IV administration of CBD, the CBD parent concentrations were shown at low levels 30 minutes after administration with a peak at 4 hours after administration.nHighlight:For IV administration, CBD was formulated in DMSO, whereas the oral formulation was in oil.nHighlight:Delivery of oral CBD in an oily formulation can lead to a phenomenon termed flip-flop kinetics, whereby the rate of absorption is substantially slower than the rate of elimination due to slow release of the drug from the vehicle.nHighlight:Cannabidiol is a very lipophilic molecule, and when combined with fats or a highly fatty diet absorption is improved in animal and humans.nHighlight:Cannabidiol is extensively metabolized in the livernHighlight:cytochrome P450 enzymesn]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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