Pharmacokinetics of cannabidiol in a randomized crossover trial in senior horses in: American Journal of Veterinary Research Volume 83 Issue 9 (2022)

1/2λ) CBD was 7.22 ± 2.86 hours for oral administration (2 mg/kg) or 3.15 ± 2.19 hours for IV administration (0.1 mg/kg),nHighlight:mean time to reach maximum concentration (T_max) was 2.46 ± 1.62 hours after oral administrationnHighlight:Mean ± SD oral bioavailability (F) for CBD administration in senior horses was 7.92% ± 2.85%.nHighlight:There were no meaningful differences in results of any of the CBC or serum biochemical analyses measures prior to or 24 hours after oral or IV administration of CBDnHighlight:There were no meaningful effects of CBD dosing on any of the vital signs measured (rectal temperature, pulse, and respiratory rate) at 30 minutes and 1 hour after administrationnHighlight:After oral or IV administration of CBD, the CBD parent concentrations were shown at low levels 30 minutes after administration with a peak at 4 hours after administration.nHighlight:For IV administration, CBD was formulated in DMSO, whereas the oral formulation was in oil.nHighlight:Delivery of oral CBD in an oily formulation can lead to a phenomenon termed flip-flop kinetics, whereby the rate of absorption is substantially slower than the rate of elimination due to slow release of the drug from the vehicle.nHighlight:Cannabidiol is a very lipophilic molecule, and when combined with fats or a highly fatty diet absorption is improved in animal and humans.nHighlight:Cannabidiol is extensively metabolized in the livernHighlight:cytochrome P450 enzymesn]]>