Loss of Caspase-1 and Caspase-3 Protein Expression in Human Prostate Cancer | Cancer Research

(16nnn, 17)n,nTGF-β1nn3nnnn(18)n, and ocadaic acidnHighlight:activation ofnTGF-β signaling suppresses prostate tumorigenicity via induction ofncaspase-1-mediated apoptosisnHighlight:Our findings indicate that thenimmunoreactivity of caspase-1 and -3 (but not caspase-9) isnsignificantly decreased in prostate cancernHighlight:Activation of the caspase cascade has been correlated with thenonset of apoptosis, and caspase inhibition attenuates apoptosis innprostate cancernHighlight:TGF-β1-mediated apoptosis induction in prostate cancer cellsnproceeds via caspase-1 activationnHighlight:The present study provides the first evidence to indicate a significantnloss of caspase-1 and -3 protein expression in human prostatic tumorsncompared with the normal gland and to implicate deregulated expressionnof caspases in prostate tumorigenesisnHighlight:down-regulation ofncaspase-1 expression in human colon cancernHighlight:annup-regulation of caspase-1 protein has been reported in pancreaticntumorsn]]>

Picture of About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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