Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

in vivo and in vitro studies confirm that HBOT induces neurogenesisnHighlight:HIF-1α is the principal mediator of cellular hypoxia adaptationsnHighlight:activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesisnHighlight:McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBInHighlight:Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patientsnHighlight:The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicitynHighlight:The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children’s overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room airnHighlight:Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluationsnHighlight:To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOTnHighlight:HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissuesnHighlight:Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD)nHighlight:HormesisnHighlight:process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stressn]]>

Picture of About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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