16] and breast cancer nHighlight:IFA revealed that both I3C and JSH-23 (data not shown) dramatically reduced viral infection in both cell typesnHighlight:targeting NF-κB activity by administering NF-κB inhibitors such as I3C may protect against SARS-CoV-2 infection at the cellular levelnHighlight:Mutations in the receptor recognition site on the S are of great concern for escaping immune surveillancenHighlight:inhibition of NF-κB can decrease the viral load by blocking viral replicationnHighlight: viral entry, replication, and egression are all mediated by NF-κBnHighlight:downregulation of NF-κB by I3C reduced cell migration (Figure 4B) and invasion (Figure 4C), suggesting that NF-κB activation is required for S (Gamma)-induced EMT phenotypenHighlight:hyperglycosylated S of Gamma variant is more stable, resulting in more significant epithelial-mesenchymal transition (EMT) potentialnHighlight:Because EMT also increases cancer cell stemnessnHighlight:I3C is a relatively non-toxic natural compound [37] and effectively prevents transmission of SARS-CoV-2 by reducing NF-κB activity.nHighlight: NF-κB can also stabilize membrane receptor expression, enabling continuous ACE2 expression to support viral entrynHighlight:I3C is an active natural anticancer compound found in cruciferous vegetables. It stabilizes IκBα and retains NF-κB in the cytoplasmnHighlight:Glycosylation reduces immunogenicity that helps pathogens escape immune surveillance.nHighlight:Compared to the SARS-CoV-2 WT, the Gamma variant induced a stronger NF-κB activation, leading to a more aggressive cancerous phenotypenHighlight:promoted NF-κB signaling activationnHighlight:single-stranded RNA virus that encodes 15 non-structural proteins (nsp1-10 and nsp12-16) as well as four structural proteins, nucleocapsid (N), membrane protein (M), envelope (E), and spike (S), for virus replicationnHighlight:Snail expressionnHighlight:Pharmacologic inhibition of NF-κB activity by nature food compound, I3C suppressed viral replication and Gamma variant-mediated breast cancer metastasisnHighlight:mRNA expression levels of viral E protein, REL, NF-κB, and IL-6 were significantly reduced in SARS-CoV-2-infected MCF10A-ACE2 cells upon I3C treatmentnHighlight:Activation of NF-κB is a hallmark of viral infectionsnHighlight:These results suggest cancer patients with COVID-19 Gamma variant infection may experience a strong potential of cancer metastasis or recurrence.nHighlight: Our earlier results showed that an S of SARS-CoV-2 induces EMT through NF-κB signalingnSticky notes:Key statement; need to read.nHighlight:downregulation of NF-κB compromised S-mediated cancer stemnessnHighlight:spike (S) glycoprotein binds to the angiotensin-converting enzyme 2 (ACE2) receptornHighlight:NF-κB inhibition can reduce chronic disease in COVID-19 patientsnHighlight:NF-κB activation is critical for SARS-CoV-2 infectionnHighlight:indicating that I3C specifically reduces NF-κB signaling without affecting the type I IFN responsenHighlight:cleaved by serine protease TMPRSS2, resulting in SARS-CoV-2 virus entrynHighlight:viruses have evolved unique and sophisticated ability to modulate NF-κB signalingnHighlight:SARS-CoV-2 activates NF-κB and, in turn, triggers the pro-survival function for cancer progressionnHighlight:over a thousand SARS-CoV-2 variants were found worldwidenHighlight:Certain viruses, such as influenza A, HIV, or HSV-1, hijack the NF-κB signal to promote viral infection by enhancing viral replicationnSticky notes:Of course, HIV is a component of this virus.nHighlight:downstream targets of NF-κB include interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNFα)nHighlight:research links breast cancer metastasis to SARS-CoV-2 infection, and we further identify I3C as one of the potent antiviral agents that can reduce S-mediated metastasisnHighlight:Gamma variant induces a stronger downregulation of E-cadherin and upregulation of N-cadherin and SNAILnHighlight:SARS-CoV-2 activates the NF-κB pathway, leading to up-regulation of inflammatory mediators such as TNFα and IL-6.nHighlight:Growing evidence suggests SARS-CoV-2 also exacerbates many chronic diseases, including cancers.nHighlight:inhibition of NF-κB by I3C can effectively reduce Gamma variant-mediated breast cancer metastasisnHighlight:Excessive NF-κBnHighlight:We observed p65 translocation from then]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


Leave a Comment

Your email address will not be published. Required fields are marked *

Skip to content