Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer | Science Advances

+ breast cancers are also positive for PR,nHighlight:In isolation, both hormones activate or inhibit cellular processes in similar directions, although the magnitude of these effects is less for progestin alone than for estrogen alonenHighlight:PR-mediated antagonism of estrogenic phenotypes is well documentednHighlight:joint activation of ER and PR antagonized ER-regulated oncogenic processesnHighlight:The presence and activity of PR significantly affect the prognostic value of ER.nHighlight:The observed loss of PR protein expression in a subset of ER+/PR+ breast cancers, because of hypermethylation or deletion of the PR gene locus, results in the loss of ER prognostic valuenHighlight:PR is an essential modulator of ER-regulated genes but also that it significantly contributes to the prognostic value of ER in ER+/PR+ breast cancersnHighlight:PR-regulated genes have independent prognostic value, and the presence of PR correlates with favorable clinicopathological outcomesnHighlight:These findings emphasize the clinical value of assessing both PR and ER expression in breast cancer samplesnHighlight:this study demonstrates that progestin-activated PR redirects ER chromatin binding and functions as a genomic estrogen agonist and as a phenotypic estrogen antagonist in ER+/PR+ breast cancer cells and human tumorsn]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


Leave a Comment

Your email address will not be published. Required fields are marked *

Skip to content