Estrogen Receptor α Is Crucial in Zearalenone-Induced Invasion and Migration of Prostate Cancer Cells

10] and esophageal cancer []; it has also been observed to have a dose-dependent effect on prostate cancernHighlight:a body of evidence indicates that ERs regulate the process of EMT through the expression of Transforming Growth Factor beta 1 (TGFβ1), E-cadherin and Hypoxia-Inducible Factor 1-alpha (HIF-1α)nHighlight:ZEA might induce both apoptosis and proliferation in prostate cancer cells in a concentration-dependent mannernHighlight:ZEA might induce both apoptosis and proliferation in prostate cancer cells in a concentration-dependent mannernHighlight:It is believed that ERα is associated with proliferation whereas ERβ plays a pro- apoptotic rolenHighlight:ZEA acts directly on prostate cancer cells via ERsnHighlight:increase in cell invasiveness, cell migration, MMP-2 and MMP-9 activity, as well as with the expression of genes associated with the EMT process, observed in the present study. This effect appears to be more associated with ERα than ERβ signalingnHighlight:a strong estrogenic signal is observed after treatment with the lower dose of ZEA (0.01 nM) [], as were greater pro- proliferative and invasive effects.n]]>

Picture of About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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