Effects of Local and Whole Body Hyperthermia on Immunity – Madame Curie Bioscience Database – NCBI Bookshelf

+ and CD4+ T cells,nHighlight:switch to an angiogenic phenotype is a fundamental determinant of neoplastic growthnand tumor progressionnHighlight:patients responsive to BRM (i.e., INF-α) show an increase in NK cell number and responders have a better prognosis as compared to non respondersnHighlight:Recent studies using WBHT in humans and animals211 did not found a decreased activity of NKs and CD4 cells in vivo, contradicting old studies in vitronHighlight:1892, a young American surgeon W. B. ColeynHighlight:Picibanil associated with hyperthermia has demonstrated in different animal strain to induce NK cell activity and to enhancentumor tissue response to heatnHighlight:Whole body hyperthermia or local hyperthermia combined with low-dose IL-2 was moreneffective on reducing tumor growth than each modality alone, and the response was more pronounced for macroscopic tumor than for microscopic onenHighlight:Cells incubated with IL-2 or INF-α had an enhancement in cytotoxicitynand number compared with control valuesnHighlight:those who developed the highest fever were most often the ones with thenlongest survivalnHighlight:an additive effect has been demonstrated without an increase in toxicitynHighlight:During LHT no detectable increase in IL-1, IL-6 or TNF-αnwas observed122 whereas after WBHT serum levels of IL-1 and IL-6 were increased.123 Robins et alnHighlight:Differently from T cells, NKs inhibit tumor growth in a MHC-non restricted mannernHighlight:Vascular Endothelial Growth Factor (VEGF)nHighlight:WBHT may induce metastases at a frequency higher than LHTnHighlight:spontaneous regression of some cancers has been demonstrated to be associated to the induction of fever and activation of immunitynHighlight:Coley should be considered the first scientist to apply with a certain continuity, inducednhyperthermia (fever) as immune treatmentnHighlight:differentiate T-Helper (CD4+) lymphocytes in two subpopulations (TH 1, TH 2 cells)nHighlight:size of the tumor and not its immunogenicitynHighlight:TNF-α increased significantly during the first 24 h, associated to a marked increase in the peripheral percentage of CTLs and CD56nHighlight:CD8+, cytotoxic T cells (CTLs) are the major effectors of tumor regressionnHighlight:abscopal responsenHighlight:regression of tumor at other anatomic sites following curative heating of primary tumor.nHighlight:WBHT at 41.8°C, an enhancement of radiation or chemotherapy response was found without a concomitant increase in myelosuppression.nHighlight:increase in the set – pointntemperature regulator found in hypothalamic areanHighlight:two factors: (A) selective increase in permeability in tumor vessels, as compared to normal tissues with a consequent accumulation of drug, (B) an augmented expression by HT of intercellular adhesion molecule -1 (ICAM-1) followed by an increased homing into tumor tissue of LAK cellsnHighlight:LAK cell cytotoxicity, as with NK cell induced cytotoxicity, decreased at temperature above 38.5 °CnHighlight:tumor regression was obtained only in presence of fevernHighlight:suppressnanti-tumor immune response principally by hampering leukocyte recruitment29 and by inhibiting CD34+ cell differentiation into dendritic cellsnHighlight:TH 1 cells produce IL-2, IFN-γ, TNF-α and granulocyte macrophage colony stimulating factor (GM-CSF) that increase the activity of macrophages, and the expression of MHC class 1 molecules on the surfaces of CD8+ cellsnHighlight:dependent on the length of treatment and the choice of temperaturenHighlight:hypoxia, acidic pH) itself unfavourably modifies T lymphocytes, NK cells and macrophagesnactivitynHighlight:Picibanil an involvement of TLR receptor 4 in its antitumor effect has been recently found demonstrating a link between innate immunity and anticancer activitynHighlight:IL-2 administered before local hyperthermia treatment has demonstrated to be additive andnuseful to treat mice with lung metastasesnHighlight:CTLsnuse three effector molecules: Perforins, Granzyme and Fas ligandnHighlight:TH 2 secretes another group of cytokines IL-4, IL-5 and IL-10, that induces naive B cells to produce antibodienHighlight:Apoptotic tumor cells in turn release Heat Shock ProteinsnHighlight:CTLs secrete specific cytokines, such as: IFN-γ, TNF-α and TNF-βnHighlight:elevated temperature, hypoxia, glucose deprivation and oxidative reagentsnHighlight:immunosuppressive TH2 pattern, permitting tumour escape from immune surveillancenHighlight:shifting towards TH 2 pattern has recently been associated with an increased tumor metastasisation and a decreased survivalnHighlight:The concentration of some adhesion molecules such as ICAM-1, L-selectin and α 4β7 have been demonstrated to be induced and increased both by LHT and WBHT, augmenting thenhoming effectnHighlight:T cell responsiveness to mitogens, IL-1, IL-2 and antigens increase linearly until a temperature of 39°CnHighlight:heat can be considered as an aspecific innate immunity boosternHighlight:immune suppressive effects of heat on NK and LAK cells become evident at temperatures above 39°CnHighlight:response was obtained using IL-2nsimultaneously to WBHT applicationnHighlight:stimulate both innate and adaptive immune systemnHighlight:Coley’s toxin” or “Mixed Bacterial Vaccine” (MBV)nHighlight:In 1868 W. Busch in Germany concluded that fever induced by certain bacteria from erysipelasncan cause tumor regression or cure cancernHighlight:streptococcal preparation OK432 (Picibanil) and Corynebacterium Parvum, can strengthen tumor lysis cells by lymphocytes when used with hyperthermia.nHighlight:heat stress increases the synthesis of HSP 70nHighlight:use of bacterial product extracts increase further this stimulationnHighlight:temperature on the order of fever range (39-40°C) is the most favourable ones for the immune responsenHighlight:intravenous routenHighlight:intracellular concentrations in CD8 cells and in serum of INF-γ and TNF-α were found elevated 24 h post WBH in the 80% of the patientsnHighlight:Immediately after WBH, a drastic increase of NK cells and CD56 CTLs was noted in peripheral bloodnHighlight:considered sufficient only if accompanied by fever (39-40°C)nHighlight:the potentiation of IL-2 combined with HT is mediated by TNF-α inductionnHighlight:Abscopal phenomena seems not pertinent to WBH treatmentnHighlight:This phenomenon was transient and followed, after 3 h post WBHn]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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