Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

11), that even tumors consisting of tumor cells resistant to a particular drug might still respond to that drug through such antivasculature “side effects.”nHighlight:significant antiangiogenic or antivascular effects in vivo in a number of assays of angiogenesis. These drugs include tubulin-inhibiting taxanes, camptothecin analogues, antimetabolites, anthracyclines, and platinum drugsnHighlight:suggested that these rest periods provide the endothelial cell compartment of a tumor an opportunity to repair some of the damage inflicted by the chemotherapynHighlight:continuous low-dose administration of methotrexate for the treatment of arthritis may have an antiangiogenic basisnHighlight: “antiangiogenic scheduling” of chemotherapynHighlight:problems can be significantly attenuated, and perhaps even avoided, by using much more frequent administration of significantly lower doses of a chemotherapeutic drugnHighlight:The dose of vinblastine used in our experiments was in the range of 1.5 mg/m2, every 3 days, which is approximately 1/4 of the MTDnHighlight:vinblastinenHighlight:topotecannHighlight:camptothecinnHighlight:paclitaxelnHighlight:minimizing toxic side effects, such as myelosuppressionnHighlight:low-dose treatment schedules.n]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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