Cancers | Free Full-Text | The Current Status of Photodynamic Therapy in Cancer Treatment

2) supply to kill tumor cells.nHighlight:PSs and O2 concentrations are considered to be two critical factorsnHighlight:both tumor microenvironment (TME)-based exogenous oxygen supplementation and endogenous oxygen consumption regulations can significantly alleviate tumor hypoxia and remarkably enhance PDT efficiencynHighlight:PS participates in electron transfer processes produce radicals and radical ions.nHighlight:ROS such as superoxide anion (O2), hydroxyl radical (OH.), and hydrogen peroxide (H2O2) can be created when free radicals combine with oxygennHighlight:PDT is involved in the oxidative damage to proteins, DNA, subcellular organelles, and blood vesselsnHighlight:immunogenic cell death (ICD)nHighlight:excessive GSH consumptionnHighlight:cell apoptosis, necrosis, or autophagynHighlight:combination therapies using two or more treatment strategies could lessen toxicity and boost the therapeutic efficiencynHighlight:Numerous non-invasive phototherapy (PDT and PTT) and chemotherapy are usednHighlight:increasing effect and decreasing toxicity”nHighlight:induce additional tumor growth inhibition with increased efficiency and lower toxicitynHighlight:remarkable synergistic therapeutic effects of PDT-based radiotherapynHighlight:Compared to monotherapy, the combination of PDT plus radiation therapy dramatically boosts the efficacy of tumor ablation.nHighlight:PDT could efficiently trigger the release of tumor-associated antigens (TAAs) and danger-associated molecular patterns (DAMPs) from cancer cells, which would contribute to eliciting potent immune responsesnHighlight:Overall, PDT combined with immunotherapy may not only improve the activity of immune cells but also reduce the immune escape of tumor cellsn]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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