Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence? – PMC

3 and α5β1 integrinsnHighlight:changes in integrin expression during SARS-CoV-2 infectionnHighlight:Several integrin-binding motifs are shown to exhibit high sequence similarity with solvent accessible regions of the spike receptor-binding domain.nHighlight:Integrins are an ancient superfamily of heterodimeric transmembrane proteins that are involved in diverse cell processes, such as cell-cell adhesion and both inside-out and outside-in cell signaling, at cell surfacesnHighlight:αVβ3, are ubiquitously expressed across human tissuesnHighlight:Because integrins are largely accessible on the surface of human cells, they are a common target for cell entry by viral pathogens nHighlight:SARS-CoV-2 spike protein directly binds αVβ3 and α5β1 integrins and may also interact with α3, β1, α4, and αX integrin subunits nHighlight:binding to the spike protein, that have been shown to mediate viral entry through the spike proteinnHighlight:Binding assays have shown that the spike protein directly interacts with α5β1 and αVβ3 integrinsnHighlight:RGD peptide were found to block the SARS-CoV-2 spike protein from binding to αVβ3 and α5β1 integrins, respectively, indicating that the spike protein binds in an RGD-dependent mannernHighlight:increases in expression suggest potential usage, while decreases in expression may rule out their involvementnHighlight:integrin expression may also be an indicator of several other altered cellular processes, such as inflammation and apoptosis, during infectionnHighlight:increased integrin expression has also been shown to enhance viral replication irrespective of binding to viral surface proteins, and decreased expression may result as a viral mechanism to prevent multiple viruses from infecting the same cell or as a defence mechanism by the hostn]]>

About Dr. Nathan Goodyear
About Dr. Nathan Goodyear

Dr. Nathan Goodyear, a medical doctor with years of experience in the field of integrative cancer care, has announced the launch of an online training program. This program, available on his new website, will provide individuals with access to video trainings led by Dr. Goodyear himself, covering a range of topics related to integrative cancer care. These trainings will include information on the latest research and techniques in the field, as well as guidance on how to incorporate these approaches into a patient’s overall cancer treatment plan. With this online program, Dr. Goodyear hopes to make his expertise and knowledge more widely accessible, and help more people understand the benefits of integrative cancer care.


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