Biomolecules | Free Full-Text | Compounds from Natural Sources as Protein Kinase Inhibitors | HTML

69] and other growth factor receptors, such as epidermal growth factor (EGFR, Her2/neu, Her3, and Her4) [21], platelet-derived growth factor (PDGFR) [70], fibroblast growth factor (FGFR) [71], vascular endothelial growth factor (VEGF) [72], and nerve growth factor (NGF)nHighlight:anchored in the plasma membranenHighlight:non-receptor tyrosine kinases (nRTKs), are localized in the cytoplasm or, in some cases, are anchored to the cell membrane through amino-terminal modification.nHighlight:Quercetin naturally occurs in different fruits and vegetables, such as apples, grapes, berries, and onions. Besides others, it is one of the earliest described flavonoids possessing inhibitory activity towards protein kinasesnHighlight:PI3K-Akt/PKB pathway is inhibited through the binding of quercetinnHighlight:Other kinases, including MEK-1, GSK-3β, Hck, and IKKα/β, have also been found to be inhibited at low micromolar levelsnHighlight:Genistein exerted inhibitory efficacy against the EGFR kinases (IC₅₀ = 22 µM), Src (IC₅₀ = 26 µM), and MEK4nHighlight:Ellagic acid is a dimer of gallic acid and can be found in several fruits and vegetablesnHighlight:Caffeic acid can be found in fruits, vegetables, wine, olive oil, and coffeen]]>